ANACIN INDUCED ADVERSE DRUG REACTION: A CASE REPORT

International Journal of Herbs and Pharmacological Research IJHPR, 2012, 1(2):30 - 32

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CASE PEPORT:

ANACIN INDUCED ADVERSE DRUG REACTION: A CASE REPORT

*1Momoh A.R.M., Momoh 2Iribhogbe O.I., Iribhogbe 3Idonije O.B., Idonije 5Uko V., Uko 4,5 4,5Akpamu U.

Department of 1Medical Laboratory Science, 2Pharmacology, 3Chemical Pathology; Faculty of Clinical Sciences;

4Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo-Nigeria. 5Anthonio Research Center, Anthonio Services Nigeria, P.O. Box 960- Ekpoma, Edo-Nigeria.

Corresponding author: mcsionelphilrazzy@yahoo.com

Received: 17th May, 2012 Accepted: 6th June, 2012 Published: 31st July, 2012

ABSTRACT

Anacin; a brand of aspirin tablets (containing 300mg acetylsalicylic acid), is a widely used analgesics. It is

recognized as one of the oldest brands of pain relievers. Its primary content is acetylsalicylic acid. Here we report a case of a 26-year old woman (64 kg in weight and 1.41m in height) who presented with adverse drug reaction secondary to Anacin ingestion following gum pain from fish bone injury. About 30mins after ingesting the drug, she presented with headache, excessive lacrimal gland secretion and facial swelling. Considering these presentations by inference, Anacin may have the potential to cause severe adverse drug reaction in some individuals. Hence, care should be taken by doctors, pharmacist and other health care providers when prescribing and monitoring patients placed on this medication. Additionally, a detailed history should be taken prior to prescribing and appropriate reporting should be made to relevant health authorities when such severe reactions are observed.

Keyword: Anacin, adverse drug reaction, pain, Acetylsalicylic acid.

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INTRODUCTION

Non Steroidal Anti Inflammatory Drugs (NSAIDs) are drugs that provide analgesic and antipyretic (fever reducing) effect and in higher doses, anti Inflammatory effect (Warden, 2010; Burke et al., 2006). They are used for painful conditions associated with swelling, redness and loss of function of the affected part (Burke et al., 2006; Rossi, 2006; Green, 2001; Gotzsche, 1989). Some like aspirin and dipyrone also have the power to reduce fever (Burke et al., 2006). Anacin; a brand of aspirin tablets containing 300mg acetylsalicylic acid, is the trade name of a widely used analgesics sold over the counter (Sanmarkan et al., 2011). Acetylsalicylic acid is used to relieve pain and bring down fever (Burke et al., 2006). It is also used in rheumatism and other conditions of bone pain. It is reported that it should not be given to children less than one year and should be used with care in asthmatic patients and all who have previously reported difficulty with breathing. Though rare, adverse drug reactions are reactions triggered by a drug’s active metabolite or by products. Specifically, adverse drug reactions are noxious or unintended reactions to a drug that is administered in standard doses by the proper route for the purpose of prophylaxis, diagnosis, or treatment of a specific disease (Vervloet and Durham, 1998; WHO 1970). Adverse reactions occur in about 5% of patients receiving any drug, and 0.03% of hospital deaths are believed to be drug-related (Fraser et al., 1999). Considering the fact that information on drug safety is of unquestionable importance (Loke et al., 2006), hence, all adverse drug reactions must be reported.

Here we reported a case of a lady who presented with adverse drug reactions secondary to Anacin ingestion.

ASN-PH-020919. ISSN: 2315-537X

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