Thursday 7 August 2014

ASSESSMENT OF SOME HEPATIC ENZYME ACTIVITIES IN ADULT RABBITS CHRONICALLY FED CRUDE GARCINIA KOLA

International Journal of Herbs and Pharmacological Research 
IJHPR, 2012, 1(1):1-6
www.antrescentpub.com

RESEARCH PAPER:

ASSESSMENT OF SOME HEPATIC ENZYME ACTIVITIES IN ADULT RABBITS CHRONICALLY  FED CRUDE GARCINIA KOLA 
*Osifo UC Osifo UC1, Ezewanne EB2, Ekhator CN , Ekhator CN1, Ozor MO
. Department of Physiology, Ambrose Alli University, Ekpoma, Nigeria. 2Department of Physiology, University of Benin, Benin city, Nigeria. 
*Corresponding Author. osifocharity@yahoo.co.uk

Received: 21st December, 2011 Accepted: 3rd February, 2012 Published: 30th April, 2012

ABSTRACT 
Therapeutic potentials of Garcinia kola (G. kola) have been extensively documented and  several researches have asserted its protective uniqueness against liver disorders/diseases. It is the aim of this study to assess the level of some enzyme involved in liver cellular integrity in rabbits chronically fed G. kola. To achieve this 
objective, twenty-four rabbits of comparable weights were randomly divided into four groups; consisting of a control (group A) and test (group B: BT1, BT2 and BT3). For 6 weeks, the control rabbits were fed standard animal feed with water given ad libitum, while doses of reconstituted G. kola powder (1200, 1500 and 1800mg G. kola per kg body mass) were administered daily by gavage to the respective test groups B aside from feed and water. At the end of the experiment, a dose depended significant increased in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities was observed. On the other hand, alkaline phosphatase (ALP) activity was significantly reduced compared to control. These results suggest that G. kola may have some biochemical influences on the liver with chronic usage and as such a need for regulation of it ingestion. 

Key words: Garcinia kola, Chronic, Crude, Liver, Male, Rabbits. 
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